High-resolution structures reveal ribosome hibernation in four Gram-negative pathogens

This study presents high-resolution cryo-electron microscopy structures of hibernating 70S ribosomes from four clinically important Gram-negative bacteria. The research identifies specific hibernation factors, HPF and YfiA, that bind to ribosomes and contribute to bacterial survival under stress and antibiotic tolerance. These findings enhance understanding of bacterial persistence mechanisms relevant to antibiotic resistance.

Originally published by gnews