CAVIN1/SULF1-Linked myCAF Signature Predicts Metastatic Progression in Colorectal Cancer

This study integrates multiple RNA sequencing datasets and transcriptomic cohorts to analyze the role of myofibroblastic cancer-associated fibroblasts (myCAFs) in colorectal cancer progression. The research identifies a myCAF signature associated with metastatic colorectal cancer, highlighting a maturation process toward an extracellular matrix-remodeling phenotype enriched in metastases. These findings were validated experimentally across clinical specimens and cell lines, providing new insights into the transcriptional dynamics of myCAF maturation in cancer metastasis.

Originally published by gnews