Liver-derived APOA1 protein improves memory and brain cell protection in Alzheimer's mice

Researchers have identified 92 proteins that cross the blood-brain barrier, including the liver-derived protein APOA1, which regulates cholesterol metabolism in astrocytes and supports neuronal synapses. In an Alzheimer's mouse model, impaired APOA1 transport was observed, but increasing its liver production reduced inflammation and amyloid abnormalities, improved synaptic integrity, and enhanced memory measures. This study highlights the potential role of liver proteins in protecting brain cells and mitigating Alzheimer's symptoms.

Originally published by gnews