PITX1 regulates epithelial identity and suppresses EMT plasticity in cells

This study identifies the transcription factor PITX1 as a key regulator that maintains epithelial cell identity and suppresses epithelial–mesenchymal transition (EMT) plasticity. Loss of PITX1 triggers changes typical of EMT, while its restoration reduces migration in aggressive breast cancer cells. These findings highlight PITX1's role in preserving tissue integrity and restraining cancer cell invasiveness.

Originally published by gnews