LMOD2 reduces Ang II-induced cardiomyocyte hypertrophy via Nrf2 antioxidant pathway

LMOD2 reduces Ang II-induced cardiomyocyte hypertrophy via Nrf2 antioxidant pathway

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This study reveals that LMOD2 expression decreases in angiotensin II-induced cardiomyocyte hypertrophy, a key factor in heart failure progression. Overexpression of LMOD2 significantly reduces cardiomyocyte enlargement and hypertrophic markers by activating the Nrf2-mediated antioxidant pathway, suggesting a protective role against pathological cardiac hypertrophy.

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Originally published by gnews