Biocatalytic aziridination enables enantioselective synthesis of chiral oxazolidinones

This report presents a novel haemprotein-catalysed aziridination and ring-expansion cascade that allows direct and enantioselective synthesis of chiral oxazolidinones. These compounds are important heterocycles widely used in asymmetric synthesis and drug discovery, particularly as scaffolds in antibiotics targeting drug-resistant Mycobacterium tuberculosis. The method addresses a gap in current synthetic strategies by enabling the installation of the 5-stereocentre, which has been underdeveloped until now.

Originally published by gnews