Coenzyme Q10 reduces methotrexate-induced salivary gland injury via antioxidant effects

Methotrexate, a common chemotherapeutic and immunosuppressive drug, often causes salivary gland toxicity through oxidative stress and inflammation. This study investigates the protective role of Coenzyme Q10, an antioxidant, in mitigating methotrexate-induced salivary gland damage using biochemical and histological analyses in rats. The findings suggest Coenzyme Q10 may reduce tissue injury by counteracting oxidative and inflammatory mechanisms.

Originally published by gnews