Tumor-associated K318N variant disrupts AGGF1 nuclear import by altering transport motifs

This study identifies three key motifs responsible for the nucleocytoplasmic distribution of AGGF1, a protein with nuclear tumor-suppressing functions. The tumor-associated K318N variant within one of these motifs disrupts AGGF1's nuclear import by interfering with its interaction with the importin α1/β1 complex. These findings clarify the molecular mechanism behind AGGF1 nuclear import regulation and its potential role in tumorigenesis.

Originally published by gnews