Large-scale study reveals sharp physiological changes at final menstrual period

This study introduces a novel computational method to analyze menopause dynamics by reconstructing final menstrual period (FMP)-anchored trajectories from large cross-sectional datasets. The analysis of 300 million lab tests from two cohorts reveals a distinct physiological 'cliff' at the FMP affecting multiple systems including endocrine, skeletal, hepatic, renal, and lipid functions. These changes are consistent across populations and absent in males, highlighting a sharper transition than previously understood.

Originally published by gnews