C3a receptor expression linked to immune profiles in clear cell renal cell carcinoma

This study explores the expression and cellular distribution of the complement receptor C3aR in clear cell renal cell carcinoma (ccRCC) and its association with the tumor immune microenvironment. Using transcriptomic analyses from the TCGA-KIRC cohort and single-cell RNA sequencing data, researchers identified distinct immune profiles related to C3aR expression. Protein expression was further validated by immunohistochemistry in an independent patient cohort.

Originally published by gnews